Whatsapp: 008615033420788

Online DoctorContact UsSite Map


Focal Segmental Glomerulosclerosis, can be reversed at the early stage. We offer the overview of FSGS basics, treatment, Symptoms ﹠ Complication and Healthy Livings.

Home > FSGS > FSGS Symptoms Complications >
Font Size A A A

Extreme Fatigue in Focal Segmental Glomerulosclerosis

Extreme Fatigue in Focal Segmental GlomerulosclerosisPatient: Recently I have become extremely fatigued. I have not seen my doctor since follow up from biopsy two months ago. Diagnosed with FSGS but no medicines at this time. The fatigue is so bad. I have no energy at all! Could I have an increase in protein spillage?

Doctor: Hi, I am glad to receive your message and here I will help you find out how FSGS and extreme fatigue linked and what causes protein spillage in FSGS.

How is FSGS and extreme fatigue linked with each other?

In most of the cases, FSGS patients suffer from extreme fatigue due to renal anemia which is a medical condition in which red blood cell account in blood is less than the reference value. Red blood cell is an important component of our blood and also the major reason to make blood red. Red blood cell circulate with blood and other substances in the blood and meanwhile carrying oxygen to our body cells. In this way, we feel energic.

In cases of FSGS, kidney tissues are injured, which can lead to the decrease of EPO (erythropoietin), a must for the synthesis of red blood cell, as EPO is normally secreted by kidney. Due to EPO insufficiency, red blood cell account decreases. Under such a condition, oxygen can not be brought to body tissues timely and patients become tired easily.

Renal anemia is the major cause of extreme fatigue in FSGS, but in some cases, patients may become fatigued for some reasons. The information your provide is limited, so it is hard to tell if you experience this problem due to renal anemia. I suggest you send your latest report to igacure@gmail.com, so that I can know your illness condition clearly and then give you more practical suggestions.

What causes protein spillage in FSGS?

In our kidney, glomerular epithelial cells and renal tubular epithelial cell play a very important role to keep protein in blood. Glomerular epithelial cells preserve protein via mechanism barrier which only allow some small molecular protein to pass through. These proteins are finally reabsorbed by renal tubule. In FSGS, when glomerular epithelial cells are injured, large amounts of protein, including protein with small molecular weight and large molecular weight, will get into urine. In such a case, patients are always told to have massive proteinuria. However, if glomeruli can work well, and renal tubular epithelial cells are damaged seriously, small molecular protein filtered by glomeruli will finally get into urine. Therefore, through special urine test, not routine urine test, we can know clearly about whether patients’ glomerular epithelial cells are damaged or their renal tubular epithelial cells are injured. In general, the more serious kidney damages are, the more serious protein spillage is.

Lastly, extreme fatigue and protein spillage are the two clinical manifestations of FSGS, if you really want to get these two problems solved, a holistic treatment that can repair kidney damages and improve kidney function is needed.

Hope the above information is helpful for you. If you have any other questions on kidney disease or want to get more personalized and professional treatment suggestions, please leave a message below.







Kidney Disease:


Related Articles
Important information in one quick click. Related Articles on IgA Nephropathy are designed to provide accurate and timely information in a short and easy to understand format. Choose the topics of interest to you and read, print or take to your next doctor visit.

Is FSGS Related to Hypertension

Is There Any Treatment Available for Glomerulosclerosis

Good Diet for FSGS Patients to Control the Inflammation

What to Do to Prevent Relapse of FSGS

Treatment for FSGS and CKD Stage 3B

Subscribe to Nephrotic
Healthy Living
Patient story
patient story
In our hospital, we have treated thousands of patients from 64 countries.


Latest Articles

Is Yogurt Good for IgA Nephropathy Patien

Because of its delicious taste and various health benefits, yogurt is a favorite for many people. Is ...

Learn More

Is Nephrotic Syndrome A Lifetime Thing

Is Nephrotic Syndrome a lifetime thing? If you are a Nephrotic Syndrome patient, you may worry about ...

Learn More

Is FSGS Related to Hypertension

Hypertension is a common clinical manifestation of FSGS. Is FSGS related to hypertension? Read on to ...

Learn More

How Can I Prevent My Son with IgA Nephrop

How can I prevent my son with IgA Nephropathy getting the flu? As we all know, infections can trigger...

Learn More