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How to Stop Passing Blood in Urine with IgA Nephropathy

Patient: My son is diagnosed with IgA Nephropathy when he was 6 years old and now he is 9. He keeps passing blood in his urine these years. What can we do to stop this condition? Can this illness be cured completely?

Doctor: Hi, thanks for emailing us: igacure@gmail.com. Passing blood in urine is a common condition among IgA Nephropathy patients. In some cases, the blood in urine only can be observed through microscope, but in some others, we can see the blood with naked eyes. Effective treatment for blood urine or hematuria caused by IgA Nephropathy is based on the pathological change which goes as follow:

IgA (Immunoglobulin A) is an antibody which should help us fight against harmful substances. However, in IgA Nephropathy, due to immune disorder, large amounts of IgA are produced in the body. They circulate with blood and may reach to any part of our body. There is a special area in our kidney that attracts IgA easily. When IgA deposits in mesangial area, inflammatory response appears, which can damage surrounding kidney tissues directly. Glomerular filtration membrane is responsible for filtering blood and preserving nutrition in the blood. When glomerular filtration membrane is damaged, many nutrient substances like protein and red blood cell will leak into urine. Urine appears like blood when red blood cell account exceeds the normal value. Since IgA Nephropathy patients pass blood in urine due to damaged glomerular filtration membrane. Therefore, only when damaged glomerular filtration membrane is repaired, can blood urine problem be solved.

In early stage of IgA Nephropathy, only a small part of kidney tissues are injured. Although these kidney cells are injured, but they are still alive. Under such a condition, it is possible to cure IgA Nephropathy. However, when illness develops to advanced stage, kidney intrinsic cells will be necrotic due to severe damages. Necrotic kidney intrinsic cells can not be revived, so IgA Nephropathy in late stage can not be cured at all. But with holistic treatment like Immunotherapy, not only further kidney damages can be cured, some injured kidney intrinsic cells can be repaired as well. Therefore, even though IgA Nephropathy can not be cured in many cases, it is possible for patients to live a high quality life.

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