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How to Reduce Creatinine 2.3 and BUN 52 In IgA Nephropathy

Patient: I have IgA Nephropathy and this was discovered last year. My recent blood panel states creatinine 2.3 and BUN 52. Is it serious? What can I do to get my creatinine level and BUN into normal range?

How to Reduce Creatinine 2.3 and BUN 52 In IgA NephropathyDoctor: I am sorry to hear you are suffering from Ig A Nephropathy. Both creatinine level and urea nitrogen level in blood can help to reflect kidney condition. Creatinine 2.3 and BUN (Blood Urea Nitrogen) 52 are not serious enough for you to start dialysis quickly, but they indeed indicate serious kidney damages.

Reference value of creatinine level varies from hospital to hospital and country to country, but it generally fluctuates in the range of 0.5-1.3mg/dL. As for BUN level, normal human adult blood should contain between 6 to 20 mg of urea nitrogen per 100ml of blood. To know clearly about how to get high creatinine level and BUN level into normal range, we need to firstly understand why creatinine level and BUN level increase with diagnosis of IgA Nephropathy.

IgA Nephropathy is a kidney problem that always brings episodic hematuria which usually starts within a day or two of a non-specific upper respiratory tract infection. In cases of IgA Nephropathy, kidney tissues are injured due to severe inflammatory response resulted from deposition of IgA in mesangial area. Both creatinine and urea nitrogen produced in our body are excreted through kidney. Therefore, when kidney function is impaired due to this illness, large amounts of creatinine and urea nirogen will build up in the blood, leading to increase of serum creatinine and BUN level. Clinical studies report serum creatinine level and BUN level begin to increase when about a half of kidney function is affected. To get creatinine 2.3 and BUN 52 lowered down to the normal range, we need to block inflammation by clearing IgA deposition away from kidney and repair kidney damages, thus to achieve the goal of preventing further kidney damages and improve kidney function. When kidney function is strengthened, creatinine level and BUN level is lowered down to the normal range successfully.

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