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Nephrotic Syndrome: Besides Uremia, What Can Threaten Your Life

Nephrotic Syndrome: Besides Uremia, What Can Threaten Your LifeDoctor: “Do you know the most common complication of Nephrotic Syndrome?”

Patient: “Blood clots, several friends died from coronary heart disease and myocardial infarction. Even if we do not develop uremia, do we also eventually die from thrombosis complications?”

As this patient said, we are not only afraid of uremia, but also of various complications, among which the highest incidence is high blood coagulation and thrombosis. It is likely to endanger the normal blood circulation of the human body. In severe case, it can cause death.

We all know that Nephrotic Syndrome has the following characteristics: 24-hour urinary protein > 3.5g, serum albumin < 30g/L, hyperlipidemia and edema. So our routine treatment is to induce diuresis to reduce edema, decrease urinary protein, and immunosuppression, but don't forget that we tend to ignore the equally important treatment - anticoagulant therapy, which should be implemented at the early stage of kidney disease, especially when serum albumin <20g/L, more attention should be paid to.

Why does Nephrotic Syndrome cause thrombus? Patients with nephrotic syndrome usually have a large amount of urine protein, which will lead to the loss of many anticoagulants, causing hypoproteinemia. This will stimulate the increase of blood coagulation factors, fibrinogen and lipoprotein synthesized by the liver, and the decrease of plasma colloid osmotic pressure, which will lead to blood concentration and thickening. In addition, frequent use of diuretics and glucocorticoids in kidney disease can also aggravate thrombosis.

The risk of thrombosis is self-evident and many patients have experienced thrombosis. We know that there are different risks at different sites. For example, renal vascular blockage will lead to a sharp deterioration of renal disease, and timely anticoagulation therapy can prevent and mitigate renal function damage. If it occurs in important position, such as pulmonary embolism, cerebral embolism and myocardial infarction, it is dangerous. Without timely treatment, it can cause serious consequence, or even threaten life.

Anticoagulation therapy can not only prevent and cure the thrombus that can take our life, but also inhibit the formation of microthrombus of glomerulus so as to prevent and control the kidney ischemia or the blood flow, which may seriously affect renal function. It can also reduce kidney disorder, decrease proteinuria, delay renal failure, and protect renal function. Therefore, anticoagulant therapy has attracted more and more attention from doctors and patients.

The choice of anticoagulant drugs is very important. The three most commonly used drugs are:

1. Antiplatelet drugs: dipyridamole, aspirin and clopidogrel, etc. Dipyridamole is relatively cheap, safe and effective, and has mild adverse reactions, such as headache, which can be tolerated by patients. It will disappear automatically after drug withdrawal.

2. Piperazine Ferulate Tablets, which contains ferulic acid, an effective component of ligustrazine in Chinese medicine. It has obvious effects on anticoagulation, reducing overall blood viscosity and inhibiting platelet aggregation.

3. Heparin and low molecular heparin. hypodermic injection. And drugs can be used in pregnant women. It is safe, not only has anticoagulant effect, but also anti-inflammation and inhibit the proliferation of mesangial cells.

In addition to drug anticoagulation therapy, you can also have appropriate activities. Eating angelica, hawthorn, salvia miltiorrhiza and other foods to promote blood circulation and remove blood stasis so as to prevent thrombosis.

Besides uremia, what can threaten your life? Now you get the answer. For more information on Nephrotic Syndrome, please leave a message below or contact online doctor.

Hope the above information is helpful for you. If you have any other questions on kidney disease or want to get more personalized and professional treatment suggestions, please leave a message below.

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