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IgA Nephropathy

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How to Deal with the Steroid-Resistant Nephrotic Syndrome

Question: My daughter has steroid resistant Nephrotic Syndrome and treatment has been unsuccessful on many medications. She has tried prednisone, tacrolimus, cyclosporine and now they want to try rituximab. Is there any other way to help my daughter out of Nephrotic Syndrome?

How to Deal with the Steroid-Resistant Nephrotic SyndromeAnswer: According to what you said, your daughter have tried and changed many medications, but all the medicine she has taken is immunosuppressant. You said she is going to try rituximab, which is also a kind of immunosuppressant. If the former medicines have no effect on her, rituximab is no exception.

Traditional treatment for Nephrotic Syndrome mainly adopts immunosuppressant therapy such as steroids and cytotoxic medicines. Immunosuppressant can achieve the effects of diuresis and eliminating proteinuria by inhibiting inflamamtion, immune response and the secretion of aldosterone and antidiuretic hormone. This therapy has quick and obvious effects to alleviate symptoms and discomforts in a short time. However, since it can not solve the underlying causes, the symptoms will once again appear under some inducement such as cold, infections or tiredness, what is more, long-term intake of steroids will cause many side effects and lower the patients’ immunity. This is especially not suitable for children because steroids can cause disorders of the internal environment and affect the children’s physical and mental development. Therefore, you should pay attention to such therapy.

Apart from immunosuppressant therapy, there are also other effective therapies for treating this disease, such as Immunotherapy. This therapy can help regulate the abnormal immune system by accurate diagnosis, immune clearance, immune blocking, immune protection, immune tolerance, and immune protection. A good immune system helps fight against kidney disease and kidney self-healing. There are also other therapies to remove waste from the blood to set up a good blood environment, such as Medicated Bath, Circle Therapy, Enema Therapy and Moxibustion.

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